Identification of Secreted Virulence Factors of Chromobacterium violaceum
2014
Castro-Gomes, T., Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil | Cardoso, M.S., Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil | DaRocha, W.D., Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, Curitiba, Brazil | Laibida, L.A., Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, Curitiba, Brazil | Nascimento, A.M.A., (Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horzonte, Brazil | Zuccerato, L.W., Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horzonte, Brazil | Horta, M.F., Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil | Bemquerer, M.P., EMBRAPA Recursos Geneticos e Biotecnologia, Brasilia, Brazil | Teixeira, S.M.R., Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Chromobacterium violaceum, a component of tropical soil microbiota, is an opportunistic pathogenic bacterium that can infect humans and other animals. In addition to identifying a large number of genes that demonstrate the vast biotechnological potential of this bacterium, genome sequencing revealed several virulence factors, including different cytolysins, which can be related to its pathogenicity. Here we confirmed these predictions from genomic analyses by identifying, through mass spectrometry, proteins present in the culture supernatant of C. violaceum that may constitute secreted virulence factors. Among them, we identified a secreted collagenase and the product of a gene with sequence similarity to previously characterized bacterial porins.
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