Effect of potassium oxalate on liver function and kidney tissue of dogs (beagles)
2013
Mohamaden, Walaa (College of Veterinary Medicine, Yangzhou, Jiangsu (China). Department of Animal Medicine) | Wang, Heng (College of Veterinary Medicine, Yangzhou, Jiangsu (China). Department of Animal Medicine) | Guan, Huawei (College of Veterinary Medicine, Yangzhou, Jiangsu (China). Department of Animal Medicine) | Li, Jianji (College of Veterinary Medicine, Yangzhou, Jiangsu (China). Department of Animal Medicine)
Calcium oxalate crystalluria is a problem of growing concern in dogs. A few reports have discussed acute kidney injury by oxalates in dogs, describing ultrastructural findings in particular. We evaluated the possibility of deposition of calcium oxalate crystals in renal tissue and its probable consequences. Six dogs were intravenously injected with 0.5 M potassium oxalate (KOx) for seven consecutive days. By the end of the experiment, ultrasonography revealed a significant increase in the renal mass and renal parenchymal echogenicity. Serum creatinine and blood urea nitrogen levels were gradually increased. The histopathological features of the kidneys were assessed by both light and electron microscopy, which showed CaOx crystal deposition accompanied by morphological changes in the renal tissue of KOx injected dogs. Canine renal oxalosis provides a good model to study the biological and pathological changes induced upon damage of renal tissue by KOx injection.
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