Hypoglycemic Effect of Jicama (Pachyrhizus erosus) Extract on Streptozotocin-Induced Diabetic Mice
2015
Park, C.J., Pusan National University, Busan, Republic of Korea | Han, J.S., Pusan National University, Busan, Republic of Korea
The purpose of this research was to investigate the inhibitory effect of jicama extract on alpha-glucosidase activity, alpha-amylase activity, and postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. Jicama extract showed prominent inhibitory effects against alpha-glucosidase and alpha-amylase. The IC50 values of jicama extract against alpha-glucosidase and Ñ-amylase were 0.083 +- 0.004 and 0.091 +- 0.017 mg/mL, respectively. The increase in postprandial blood glucose levels was more significantly suppressed in the jicama extract-administered group than in the control group of both STZ-induced diabetic and normal mice. Blood glucose levels of the control group increased to 383.75 +- 11.54 and 402.50 +- 15.32 mg/dL at 30 and 60 min after a meal and decreased to 349.67 +- 11.62 mg/dL at 120 min. However, postprandial blood glucose levels were significantly decreased, when diabetic mice were fed with jicama extract (342.00 +- 15.73, 367.00 +- 13.00, and 329.67 +- 12.43 mg/dL at 30, 60, and 120 min, respectively). Furthermore, the area under the curve was significantly decreased with jicama extract administration in diabetic mice (P¡Õ0.05). Therefore, these results indicate that jicama extract may help decrease postprandial blood glucose level by inhibiting alpha-glucosidase
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