NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-kB and Reactive Oxygen Species Pathways
2015
Kim, J.H., Chonnam National University Medical School, Gwangju, Republic of Korea | Kim, K., Chonnam National University Medical School, Gwangju, Republic of Korea | Kim, I., Chonnam National University Medical School, Gwangju, Republic of Korea | Seong, S., Chonnam National University Medical School, Gwangju, Republic of Korea | Kim, N., Chonnam National University Medical School, Gwangju, Republic of Korea
Negative regulator of reactive oxygen species (NRROS) is known to repress ROS generation in phagocytes. In this study, we examined the roles of NRROS in both osteoclasts and osteoblasts. Our results demonstrate that NRROS negatively regulates the differentiation of osteoclasts, but not osteoblasts. Further, overexpression of NRROS in osteoclast precursor cells attenuates RANKL-induced osteoclast differentiation. Conversely, osteoclast differentiation is enhanced upon siRNA-mediated knockdown of NRROS. Additionally, NRROS attenuates RANKL-induced NF-¥êB activation, as well as degradation of the NOX1 and NOX2 proteins, which are required for ROS generation. Based on our observations, we present NRROS as a novel negative regulator of RANKL-induced osteoclastogenesis.
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