Supplementation of GABA-B receptor antagonist (CGP 55845), following hypoxia ischemia encephalopathy moderately affects the hematological and serum biochemical profile in albino mice
2015
Khadim, N. (Bahauddin Zakariya Univ., Multan (Pakistan). Inst. of Pure and Applied Biology, Zoology Div.) | Iqbal, S. (Bahauddin Zakariya Univ., Multan (Pakistan). Inst. of Pure and Applied Biology, Zoology Div.) | Gillani, Q.A. (Bahauddin Zakariya Univ., Multan (Pakistan). Inst. of Pure and Applied Biology, Zoology Div.) | Safdar, S. (Pakistan Medical Research Center, Multan (Pakistan). Nishter Medical Coll.) | Iqbal, F.
Present study was conducted to report the effect of 1mg GABA-B receptor antagonists (CGP55845; 3-N [t-(S)-(3,40-dichlorophenyl) ethyl] amino-2-(S)-hydroxypropyl-P-benzyl-phosphinic acid) / kg body weight/ml of solvent injected for 12 days following hypoxia ischemia encephalopathy on postnatal day 10 on hematological and serum biochemical profile of albino mouse. Blood samples from 34 albino mice (18 CGP55845 treated and 16 saline treated) were collected from direct cardiac puncture and various hematological parameters such as blood glucose, packed cell volume (PCV), total WBC (TWBC) count, total RBC count and serum biochemical parameters, such as cholesterol, aspartate transaminase, alanine transaminase (ALAT) high density lipoprotein, low density lipoprotein, total protein and triglycerides were determined. Glucose, MCV, TWBC and PCV concentrations in male and TWBC and PCV concentrations in females decreased significantly in CGP55845 treated albino mice. Triglycerides and ALAT were significantly increased in the CGP55845 treated albino mice.
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