Resveratrol reduces oxidative stress and improves arsenic efflux in rats exposed to arsenic trioxide
2016
Zhang, W. (Northeast Agricultural Univ., Harbin (China). Coll. of Veterinary Medicine) | Liu, Y. (Inner Mongolia University for Nationalities, Tongliao (China). School of Life Sciences) | Ge, M. (Northeast Agricultural Univ., Harbin (China). Coll. of Veterinary Medicine) | Yao, C. (Inner Mongolia University for Nationalities, Tongliao (China). Coll. of Animal Science and Technology) | Xue, J. | Zhang, Z.
The effects of resveratrol on arsenic trioxide-induced oxidative stress and arsenic efflux in spleen were determined in Wistar rats exposed to arsenic trioxide (As2O3). Wistar rats were segregated into four groups: control (0.9% normal saline), As2O3-treated (2 mg/kg for 7 days, i.p.), resveratrol + As2O3-treated, resveratrol- treated (5 mg/kg for 7 days, i.p.). Spleen was analyzed for lipid peroxidation, antioxidant enzyme activities, glutathione redox system and arsenic accumulation. Arsenic treatment showed significant increases in the malondialdehyde, reactive oxygen species and arsenic accumulation in spleen. Furthermore, arsenic treatment decreased significantly activity of superoxide dismutase & total glutathione/oxidized glutathione ratio. However, treatment with resveratrol to arsenic-treated rats reduced oxidative stress and improved arsenic efflux. These findings may provide the potential strategy for arsenic-induced spleen toxicity and As2O3 as a single agent causing toxic effects.
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