Interleukin 10 suppresses the function of mouse bone marrow-derived dendritic cells infected with classical swine fever virus C-strain
2016
Fu-Ying, Z. (Chinese Academy of Agricultural Sciences, Lanzhou (China). Lanzhou Veterinary Research Inst.) | Guo-Zhen, L. (Chinese Academy of Agricultural Sciences, Lanzhou (China). Lanzhou Veterinary Research Inst.) | Zhi-Zhong, J. (Chinese Academy of Agricultural Sciences, Lanzhou (China). Lanzhou Veterinary Research Inst.)
Interleukin (IL)-10 inhibits the functions of antigen-presenting cells (APCs), including dendritic cells (DCs), however, the precise mechanism of action of IL-10 has not been fully elucidated. In this work, the effects of IL-10 on classical swine fever virus (CSFV) C-strain-infected mouse bone marrow-derived immature DCs (BM-imDCs) were studied. Additional IL-10 suppressed the maturation of the infected BM-imDCs by down-regulating the expression levels of the surface molecules CD80, CD86 and major histocompatibility complex (MHC) class II, while the autocrine IL-10 had no significant effect on the maturation status of the cells. Both additional and autocrine IL-10 markedly inhibited the secretion production of IL-12P40 derived from the BM-imDCs infected with the C-strain, and reduced the capacity of DCs to promote allogeneic naive T cell proliferation. These results showed that IL-10 may play an important role in the DCs-dependent immune response induced by CSFV C-strain.
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