Influence of epinephrine and medetomidine on systemic absorption of lidocaine applied epidurally in anesthetized swine
2014
Lipar, Marija (Faculty of Veterinary Medicine, Zagreb (Croatia). Clinic for Surgery, Orthopedics and Ophthalmology) | Turner, Rajka | Radišić, Berislav (Faculty of Veterinary Medicine, Zagreb (Croatia). Clinic for Surgery, Orthopedics and Ophthalmology) | Grgurević, Lovorka (School of Medicine, Zagreb (Croatia). Department of Anatomy, Laboratory for Mineralized Tissues) | Erjavec, Igor (School of Medicine, Zagreb (Croatia). Department of Anatomy, Laboratory for Mineralized Tissues) | Brajenović, Nataša (Institute for medical research and Occupational Health, Zagreb (Croatia)) | Brčić-Karačonji, Irena (Institute for medical research and Occupational Health, Zagreb (Croatia)) | Samardžija, Marko (Faculty of Veterinary Medicine, Zagreb (Croatia). Clinic for Reproduction and Obstetrics) | Vnuk, Dražen (Faculty of Veterinary Medicine, Zagreb (Croatia). Clinic for Surgery, Orthopedics and Ophthalmology)
Epinephrine and alpha 2 agonist drugs are often used with epidural anesthesia to minimize local anesthetic systemic absorption, as well as to prolong the duration of the block. The aim of the current study was to determine by which extent epinephrine and medetomidine influenced lidocaine systemic absorption rate following epidural application. This was achieved by monitoring the serum lidocaine concentration in a porcine model. During general anesthesia, the first group received epidurally plane lidocaine, the second received lidocaine containing epinephrine (1:80.000), and the third lidocaine with medetomidine (15 μg/kg). Venous blood samples were taken before and 5, 10, 20, 30, 45, 60 and 90 minutes following epidural administration of the anesthetic. The effects of epinephrine and medetomidine were comparable. They both failed to cause a significant decrease in serum lidocaine concentration (p>0.05). In these settings we were unable to demonstrate a greater capacity of these two adrenergic agonists for reducing lidocaine systemic uptake and, accordingly, its systemic toxicity potential.
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