Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs
2017
Mongillo, P., University of Padova, Legnaro, Italy | Bernardini, M., University of Padova, Legnaro, Italy | Prana, E., University of Padova, Legnaro, Italy | Balducci, F., Portoni Rossi Veterinary Hospital, Zola Predosa, Italy | Gabai, G., University of Padova, Legnaro, Italy | Marinelli, L., University of Padova, Legnaro, Italy
Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.
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