Hangover relieving effect of Sanghwang mushroom mycelium cultured in germinated buckwheat
2017
An, Y.J., Jeju National University, Jeju, Republic of Korea | Cho, S.M., Jeju National University, Jeju, Republic of Korea | Kim, M.S., Jeju National University, Jeju, Republic of Korea | Moon, H.H., Jeju National University, Jeju, Republic of Korea | Park, D.S., Jeju Sanghwang Co.,Ltd., Jeju, Republic of Korea | Jeon, N.G., Jeju Sanghwang Co.,Ltd., Jeju, Republic of Korea | Lee, Y., Jeju National University, Jeju, Republic of Korea | Han, C.H., Jeju National University, Jeju, Republic of Korea
The present study was performed to evaluate the hangover relieving effect of germinated buckwheat (GB) and Sanghwang mushroom mycelium cultured in GB (SGB). Both GB and SGB showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities and significantly increased (p less than 0.001) aldehyde dehydrogenase (ALDH) activities; up to 140% increase at concentrations of 16 μL/mL. Locomotor activity test results from alcohol-SGB and alcohol-GB groups showed improved motor activities over that of the alcohol-water group at 90 min post-administration. Both alcoholGB and alcohol-SGB groups had significantly reduced (p less than 0.001) alcoholand aldehyde concentrations in blood compared to those in the alcohol-water group at 90 min post-administration. Based on cDNA microarray analysis, expressions of ALDH genes ALDH1a7 and ALDH18a1 and cytochrome P450 (CY450) gene CYP4a30b were upregulated in the alcohol-GB and alcohol-SGB groups compared to levels in the control group. Overall, the results suggest that both GB and SGB have hangover relieving effects by reducing blood acetaldehyde levels. The molecular mechanisms may involve ALDH activation and upregulated expression of alcohol metabolism-related genes such as ALDH and CYP450.
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