Effects of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini Extracts on Melanin Synthesis in Melanoma Cells
2017
Kim, M.J., Nakdonggang National Institute of Biological Resources, Gyeongbuk, Republic of Korea | Kim, S., Jeju National University, Jeju, Republic of Korea | Hyun, K.H., Helios., Jeju, Republic of Korea | Kim, D.S., Jeju National University, Jeju, Republic of Korea | Kim, S.Y., Sunmoon University, Chungnam, Republic of Korea | Hyun, C.G., Jeju National University, Jeju, Republic of Korea
In this study, we investigated the effect of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini extracts on tyrosinase activity and melanin production as natural products of whitening functional cosmetics. To measure the melanin production, 50, 100, 200 microgram/mL of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini extracts were treated on alpha-MSH treated B16F10 melanoma cells, respectively. Melanin contents in alpha-MSH treated B16F10 melanoma cells were decreased by 41.5, 51.11, and 61% in 200 microgram/mL treatment compared to none treatment, respectively. In addition, the intracellular tyrosinase activity was decreased after treatments with all extracts. Furthermore, 100 microgram/mL of Euphoibia jolkini extract was decreased 81.5% of melanin production in B16F10 melanoma cells. When the three extracts were compared, Euphoibia jolkini extract was considered to be the most functional material for whitening effect.
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