Fraktalna dimenzija i neurotoksičnost kod pacova intoksiranih aluminijumom / Fractal dimension and neurotoxicity in rats intoxicated by aluminium
2015
Martać, Ljiljana (Institut za biološka istraživanja Siniša Stanković, Beograd (Srbija). Odeljenje za neurofiziologiju)
We used animal model of neurotoxicity in rats, which provided the possibility of study- ing biological pathophysiological phenomena in vivo and afterwards in vitro conditions. The analysis of electrocortical brain activity using mathematical methods can describe the changes induced by aluminum intoxication in rat as an animal model. In physiological and pathophysiological conditions, on experimental models, mechanisms related to changes in behavior, plasticity and accumulation of aluminum in nervous tissue of the rat brain were observed. Animal models of rats used in the experiments described changes in the group of neuronal activity in the brain of rats in different modes of intoxication aluminum. This study describes ECoG activity in the brain of rats under anesthesia in both the control and aluminum treated animals. Fractal and spectral analysis was used to present qualitative and quantitative changes in the conditions of neurotoxicity. Changes in neuro- transmission, as well as the structure and function of the neural network are connected to the molecular-physiological mechanisms of neurotoxicity. Aluminium toxicity was moni- tored through changes in glutamatergic activity and calcium channel activity. By spectrum analysis neurotoxicity was described through changes in spectral power in the correspond- ing frequency ranges. By comparing the FD of intoxicated and control individuals there was obtained the range of the change in correlation with the corresponding pathophysio- logical conditions of intoxication. The shange in FD might be an indication of neurotoxicity.
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