Access denied : A closer look at anti-phage defense mechanisms
2018
Vlot, Marnix
Microorganisms are under constant threat by their viruses, bacteriophages (phages). In response to this pressure, they have developed multiple strategies to protect from phage infection. Mechanisms that protect microorganisms from phage infection include restriction-modification, BREX, DISARM, and CRISPR-Cas systems. However, phages have developed several mechanisms by which they can evade anti-phage defense systems. One common way to evade these systems by phages is by modifying their nucleic acids (DNA). This thesis encompasses the characterization of several CRISPR-Cas and DISARM proteins and studying the effect of phage DNA modifications on the activity of these proteins.
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