Neuroprotective effects of α-Lipoic acid alone and in combination with ferulic acid in diabetic neuropathy induced rats
2020
Gupta, Sneha | Sherikar, Abdullah | Upaganlawar, Aman | Upasani, Chandrashekhar
The present pre-clinical activity was undertaken to screen the two antioxidants, mainly α-lipoic acid and ferulic acid alone, and in combination in neuropathic pain induced by diabetes in rats. The activity was confirmed by assessing various behavioral as well as biochemical and histopathological studies. The study was performed on adult albino rats. The rats were divided into different groups, and each group contained six rats. Diabetic neuropathy in rats was induced by administering a freshly prepared single dose of streptozotocin (60mg/kg, i.p). After development of neuropathy the rats were treated with α-lipoic acid (25mg/kg/day, p.o), ferulic acid (10mg/kg/day, p.o) and standard drug Pregabalin (30mg/kg/day i.p). One group received the combination of antioxidants, i.e.,α-lipoic acid (12mg/kg, p.o) and ferulic acid (05 mg/kg/day, p.o) respectively, for two weeks. Neuropathic pain was assessed using mechanical allodynia, mechanical hyperalgesia, cold allodynia, and thermal allodynia. Biochemical Parameters such as blood glucose, nitric oxide, level of lipid peroxidase, reduced glutathione, and membrane-bound ATPases activities were also studied. Neuropathic pain induced rats showed a significant alteration in behavioral and biochemical parameters. Treatment with α-lipoic acid in combination with Ferulic acid significantly restored the altered parameters towards normal as compared to single antioxidants, thus provided proper neuroprotection. This effect might be due to the strong free radical scavenging potential of α-lipoic acid and ferulic acid.
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