Antiviral activity of water extracts of some medicinal and nutritive plants from the Apiaceae family
2020
GabAllah, Mohamed | Ahmed, Kandeil | Abd El-Baset Mousa, Adel | Ahmed Ali, Mohamed
During the past two decades, several human infections with avian influenza H5N1 virus have been reported.An increase in the recorded cases of human viral infections led to more public health concern, because of theirpotential pandemic proportions in the human's society. Moreover, an increase in the cases of drug-resistantinfluenza A virus has brought the urgent need for alternative anti-influenza drugs. In the present study, waterextracts from eight commonly available medicinal and nutritive plants from the Apiaceae family including; Dill,Celery, Caraway, Coriander, Cumin, Fennel, Anise, and Parsley were prepared. The cytotoxicity of each ofextract was individually determined in the Madin–Darby canine kidney (MDCK) cells. Thereafter, these extractswere investigated for their in vitro antiviral activities against the avian influenza H5N1 virus infection. Currentresults revealed that water extracts of the eight plants showed antiviral inhibitory activities with percentagesranging from 0- 71%. Among the tested plants, only anise plant (Pimpeniella anisum) had significant antiviralactivity against the avian influenza H5N1 virus. Thus, the mode of action of this effective anise extract wasinvestigated against the same virus. It was found that water extract of the anise plant induced virucidal effect, aswell as direct effect on replication of the avian influenza H5N1 virus. The aim of the present study was to shedlight on searching for alternative therapeutic sources for future treatment of the H5N1 influenza virus infection.
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