Towards a realistic and integrated strain design in batch bioreactor
2018
jeanne, guillaume | Goelzer, Anne | Tebbani, Sihem | dumur, didier | Fromion, Vincent
Recent advances in modeling bacterial cell functioning have deeply renewed questions about bioprocess design and opens the way towards the development of computer aided design (CAD) for strains. This article aims at explaining and exploring the consequences opened by the new cell models, investigating the questions related to the biological implementation of optimal strategies and in conclusion the possible role of the complex regulatory network in the retuning of the strain.
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