Perinatal prebiotic supplementation has later consequences on adult metabolism and immunity in pig as human model
2015
Le Bourgot, Cindy | Blat, Sophie | Ferret-Bernard, Stéphanie | Apper, Emmanuelle | Respondek, Frédérique | Le Huërou-Luron, Isabelle
Perinatal nutrition, a key factor controlling gut bacterial colonization, may have lastingconsequences on health. We investigated whether early short-chain fructooligosaccharide(scFOS) supplementation, known to well-balance microbiota, impacted adult metabolic andimmunologic responses to a high-fat (HF) diet.Sows received a supplementation with scFOS or not for the last 4 weeks of gestation and thelactation. The scFOS supplementation was maintained in piglets weaned from scFOS sows tillpostnatal day (PND) 56. Twenty four piglets were then fed a standard diet until PND190, thena HF diet for 12 weeks.Early scFOS supplementation increased faecal short-chain fatty acid production after 3 weeksof HF diet but this effect was not observed later. Ongoing metagenomics analysis will givemore insights on microbiota composition changes. Insulin response to a glucose challenge(IVGTT) tended to increase in scFOS group, but no other metabolic parameter was modified(lipid metabolism, basal glycaemia and insulinemia, insulin pancreatic content). Preliminaryresults showed a modulation of the pro-inflammatory cytokine secretion (IFNg , TNFa, IL-8)by ex vivo stimulated ileal explants and MLN cells, revealing a modification of localimmunity orientation with perinatal scFOS supplementation.Our results underline the key role of early microbiota modulation on adult responses to anutritional challenge.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Institut national de la recherche agronomique