An open label trial of anakinra to prevent respiratory failure in COVID-19
2021
Evdoxia Kyriazopoulou | Periklis Panagopoulos | Symeon Metallidis | George N Dalekos | Garyphallia Poulakou | Nikolaos Gatselis | Eleni Karakike | Maria Saridaki | Georgia Loli | Aggelos Stefos | Danai Prasianaki | Sarah Georgiadou | Olga Tsachouridou | Vasileios Petrakis | Konstantinos Tsiakos | Maria Kosmidou | Vassiliki Lygoura | Maria Dareioti | Haralampos Milionis | Ilias C Papanikolaou | Karolina Akinosoglou | Dimitra-Melia Myrodia | Areti Gravvani | Aliki Stamou | Theologia Gkavogianni | Konstantina Katrini | Theodoros Marantos | Ioannis P Trontzas | Konstantinos Syrigos | Loukas Chatzis | Stamatios Chatzis | Nikolaos Vechlidis | Christina Avgoustou | Stamatios Chalvatzis | Miltiades Kyprianou | Jos WM van der Meer | Jesper Eugen-Olsen | Mihai G Netea | Evangelos J Giamarellos-Bourboulis
Background: It was studied if early suPAR-guided anakinra treatment can prevent severe respiratory failure (SRF) of COVID-19.Methods: A total of 130 patients with suPAR ≥6 ng/ml were assigned to subcutaneous anakinra 100 mg once daily for 10 days. Primary outcome was SRF incidence by day 14 defined as any respiratory ratio below 150 mmHg necessitating mechanical or non-invasive ventilation. Main secondary outcomes were 30-day mortality and inflammatory mediators; 28-day WHO-CPS was explored. Propensity-matched standard-of care comparators were studied.Results: 22.3% with anakinra treatment and 59.2% comparators (hazard ratio, 0.30; 95% CI, 0.20–0.46) progressed into SRF; 30-day mortality was 11.5% and 22.3% respectively (hazard ratio 0.49; 95% CI 0.25–0.97). Anakinra was associated with decrease in circulating interleukin (IL)−6, sCD163 and sIL2-R; IL-10/IL-6 ratio on day 7 was inversely associated with SOFA score; patients were allocated to less severe WHO-CPS strata.Conclusions: Early suPAR-guided anakinra decreased SRF and restored the pro-/anti-inflammatory balance.Funding: This study was funded by the Hellenic Institute for the Study of Sepsis, Technomar Shipping Inc, Swedish Orphan Biovitrum, and the Horizon 2020 Framework Programme.Clinical trial number: NCT04357366.
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