Tk-deleted pseudorabies virus retains high pathogenicity in rats
2021
Zhang Lirong | Ruan Keyue | Sang Guoju | Xu Zhaoyang | Tong Wu | Yu Hai | Shan Tongling | Gao Fei | Li Liwei | Kong Ning | Tong Guangzhi | Zheng Hao
The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion. The aim of the study was to assess the pathogenicity of tk-deleted PRV in rats.
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