The use of different progestin devices in ovarian stimulation protocol affects gene expression in sheep cumulus-oocyte complexes (COC).
2019
BRAGANÇA, G. M. | BATISTA, R. I. T. P. | SOUZA, C. V. | SANTOS, J. D. R. | ARASHIRO, E. K. N. | FONSECA, J. F. da | BRANDÃO, F. Z. | SOUZA-FABJAN, J. M. G.
Progesterone (P4) and its analogues (progestins) are commonly used in estrus synchronization protocols and to hold the LH surge during ovarian stimulation to allow oocyte recovery in live donor ewes. However, recent evidence suggests that some progestins may have a deleterious effect on embryo quality after long-term use. Thus, the present study aimed to evaluate the effect of two progestin devices used during ovarian stimulation on the COC quality in donor ewes. In conclusion, the progestin device alters the expression of genes related to quality and the steroidogenesis pathway in fully-grown COCs, and the use of a natural P4 device may improve the development competence of COCs. Further studies including IVP are necessary to confirm our findings.
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