Telomeric repeat (TTAGGG)(n) sequences of human chromosomes are conserved in chimpanzee (Pan troglodytes)
1993
Luke, S. (Long Island Coll. Hospital, Brooklyn, NY (USA). SUNY Health Science Center. Div. of Genetics) | Verma, R.S.
Using a series of genetic parameters, attempts have been made for more than two decades to establish the close kinship of human (Homo sapiens) with chimpanzee (Pan troglodytes). Molecular and cytogenetic data presently suggest that the two species are closely related. The recent isolation of a human telomeric probe (P5097-B.5) has prompted its cross hybridisation to chimpanzee chromosomes in order to explore convergence and/or divergence of the telomeric repeat sequences (TTAGGG)(n). On hybridization, the human probe bound to both ends (telomeres) of chimpanzee chromosomes, suggesting a concerted evolution of tandemly repeated short simple sequences (TTAGGG)(n). Even the terminal heterochromatin of chimpanzee chromosomes was found to be endowed with telomeric repeats, suggesting that evolution of heterochromatin and capping with tandemly repeated short sequences are highly complex phenomena.
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