Studies on the role of liver cytochrome P-450 and oestradiol metabolism in the effects of nutrition and phenobarbital on ovulation rate in the ewe
1991
Payne, E. | Smith, J.F. | Cope, B.C. | McGowan, L.T. (MAF Technology, Hamilton (New Zealand). Ruakura Agricultural Centre)
Phenobarbitol, triacetyloleandomycin (TAO), high liveweight due to feeding before treatments were imposed, and a current diet high in protein were all found to increase the ovulation rate of ewes, while carbon tetrachloride treatment reduced it. Effects on liver weight and microsomal protein each showed the same patterns. Phenobarbital and TAO increased cytochrome P-450 and associated enzyme activities. Most of the data support the theory that nutritionally induced increases in ovulation rate in ewes could result from changes in oestradiol metabolism but there is a suggestion that protein diet and high liveweight may be acting through several metabolic mechanisms.
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