Vascular leakage induced by histamine, bradykinin, serotonin, and prostaglandin E2 in greyhounds [dogs]
1993
Mills, P.C. | Ng, J.C. | Seawright, A.A. (Queensland Univ., St Lucia (Australia). Dept. of Veterinary Pathology) | Auer, D. (Queensland Government Racing Science Centre, Albion (Australia))
Intradermal injections of histamine, bradykinin and serotonin were applied alone or with co-injections of prostaglandin E2. At equimolar concentrations, histamine was more than twice as potent in inducing vascular leakage as bradykinin. Serotonin did not induce leakage and was irritant. Prostaglandin E2 did not induce leakage, but increased the effects of both histamine and bradykinin; more so at lower levels of administration. Histamine was most effective during the first 5 min of lesion development, bradykinin during the second, and the synergistic effect of prostaglandin E2 during the third 5 min.
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