An analysis of the sequence of part of the right arm of chromosome 2 of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidase
1994
Nasr, F. (Universite Pierre et Marie Curie, Gif-sur-Yvette (France). Lab. Centre National da la Recherche Scientifique. Centre de Genetique Moleculaire) | Becam, A.M. | Grzybowska, I.E. | Zagulski, M. | Slonimiski, P.P. | Herbert, C.J.
Two new genes, YBR1007 and YBR1015, were analyzed that were discovered during the systematic sequencing of chromosome 2 of Saccharomyces cerevisiae. YBR1007 shows strong similarities to amino-acid permeases, in particular the high-affinity proline permeases of S. cerevisiae and A. nidulans. The number and position of the predicted membrane-spanning domains suggest a conserved structure for these proteins, with 12 trans-membrane domains. YBR1015 shows strong similarities to serine carboxypeptidases; all three residues of the "catalytic triad" typical of this family of enzymes are conserved in the YBR1015 protein. In a preliminary functional analysis a null allele of the YBR1015 gene was created and it was shown that it is not essential for cellular viability.
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