New data on the treatment of bovine hypodermosis with metrifonate (Neguvon) and ivermectin (Ivomec) microdoses | Donnees recentes sur le traitement de l'hypodermose bovine au moyen de metrifonate (Neguvon) et d'ivermectine (Ivomec) en microdoses
1997
Charbon, J.-L. | Pfister, K. (Laboratoire Pfister, Bern (Switzerland))
Large-scale preventive treatments against bovine hypodermosis have been performed in the canton of Grisons and in different Jura areas (Switzerland). Either Metrifonate (Neguvon 10 % spot-on, Bayer AG) or Ivermectin microdoses (i.e. 0.1 ml Ivomec ad.inj. - MSD AGVET - per animal) were applied. The treatment of dairy cows with Neguvon at the then recommended dose (24 ml/animal) showed a low efficacy of 80 %, without any correlation to the date of treatment. An increase of the dose to 36 ml/animal revealed an efficacy of 93 %, while a weight-dependent dose of 6 ml/100 kg body weight reduced the warble infestation by 97.3 % without any drug-related side effects. The few observed side effects - salivation and mild meteorism - are likely to be due to the destruction of Hypoderma lineatum larvae in the gullet of treated cows. No case of abortion was reported. The Ivomec microdose applied to young animals or dry cows showed and efficacy 99.8 %. The available drugs would thus allow a quick and efficacious control of bovine hypodermosis, provided they are used systematically and at an appropriate dose in endemic areas
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