The effectiveness of inactivated, purified and concentrated experimental rabies vaccine for veterinary use: antigenic activity. Experiments on domestic dogs
1998
Benisek, Z. | Sueliova, J. | Svrcek, S. | Ondrejka, R. | Durove, A. (Univerzita Veterinarskeho Lekarstva, Kosice (Slovak Republic)) | Zavadova, J.
The antigenic activity of experimental inactivated, concentrated, purified adjuvant rabies vaccine prepared by the authors was investigated in experiments on domestic dogs and compared with antigenic activity of commercial rabies preparations with intramuscular application. The effectiveness of experimental vaccine was tested in domestic dogs also by non-traditional intradermal method of application at varying doses (0.1 and 0.2 cm**3). The results of determination of rabies antibodies by means of VNT (virus neutralization test) and ELISA method with intramuscular administration of vaccines revealed that the antigenic activity of the experimental vaccine is comparable with that of commercial preparations. The effectiveness of the experimental vaccine with intradermal administration at a dose of 0.2 cm**3 was even higher. The dose of 0.1 cm**3, administered intradermally, cannot ensure adequate antirabies protection for the period of 15 months.
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