Myocytes changes and satellite cells proliferation following denervation of ALD (Anterior Latissimus Dorsi) and PLD (Posterior Latissimus Dorsi) muscles in two strains of turkey (Meleagris gallopavo)
2014
Bakou, S | Guigand, Lydie | Apreutese, Radu | Apreutese, A | Wyers, Monique
Morphological features and chronology of myocytes changes after denervation were studied over 35 days period in 2 heavy (HW) and light-weight (LW) strains of 5-week-old male turkeys. Denervation caused progressive atrophy in posterior latissimus dorsi (PLD). By day 28, the weight of the PLD muscle had reached about 62% of the non-denervated contralateral muscle weight in both strains. On the contrary, ALD muscle mass increaseprogressively after denervation. Thus the maximum hypertrophy of the ALD, expressed as a percentage of contralateral muscle, was respectively about 67% and 37%,day 21 in the HW strain and day 28in LW strain after denervation. ALD hypertrophy ceased apparently after day 21 (HW strain) and day 28 (LWstrain). Morphometric analysis revealed that fast twitch (type II) fibers were atrophied after denervation, whereas slow tonic (type III) fibers were hypertrophied from day 7.Coagulative necrosis with fragmentation and lysis associated with moderate infiltration of inflammatory cells, were similar in both strains. Irregularities in mitochondrial distribution occurred mainly in type III fibers of ALD muscle at day 7. Seven and 14 days after denervation, immunolabelling of proliferating cell nuclear antigen (PCNA) revealed satellite cell activation in denervated muscles. The number of activated satellite cells was greater in the LW than HW mainly in ALD muscles
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