Approach to Functions of <i>BHLHE41/DEC2</i> in Non-Small Lung Cancer Development
2023
Tatsuhiko Furukawa | Kentaro Mimami | Toshiyuki Nagata | Masatasu Yamamoto | Masami Sato | Akihide Tanimoto
The circadian rhythm-related genes <i>BHLHE40/DEC1</i> and <i>BHLHE41/DEC2</i> have various functions under different cell and tissue conditions. <i>BHLHE41/DEC2</i> has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of <i>BHLHE41/DEC2</i> on differentiation have been examined using <i>Bhlhe41/Dec2</i> knockout mice and/or in vitro differentiation models, and research has been conducted using genetic analysis of tumor cells, in vitro analysis of cancer cell lines, and immunohistochemical studies of the clinical samples. We summarize some of these studies, detail several problems, and consider possible reasons for contradictory results and the needs for further research.
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