Biochemistry of nickel
1993
Hausinger, Robert P.
Nickel is typically known for its harmful effects on biological systems and for its carcinogenic properties, but it is also essential to various metabolic processes of microorganisms, plants, and animals.
Show more [+] Less [-]In this volume, Robert P. Hausinger provides balanced coverage of nickel biochemistry, thoroughly discussing both the harmful and beneficial effects of this important metal ion. The opening chapter presents a historical overview of nickel, delineating its concentrations, distributions, and fluxes in the environment.
Show more [+] Less [-]Subsequent chapters describe the coordination chemistry and spectroscopic properties of nickel; the properties of the nickel-containing enzymes - urease, hydrogenase, carbon monoxide dehydrogenase, and methyl coenzyme M reductase - and their novel nickel metallocenters; elaborate biosynthetic systems that function specifically to incorporate nickel into certain nickel-dependent proteins; nickel transport, toxicity, and resistance mechanisms in microorganisms; plant-nickel interactions, including the unique nickel hyperaccumulating plants; the mechanisms for nickel uptake, transport, and elimination in animals; and essentiality of nickel and its toxic and carcinogenic effects in animals. A critical and up-to-date reference on the biological interactions of this key metal ion, Biochemistry of Nickel will be a valuable handbook for researchers and will serve to stimulate further study in this rapidly evolving field.
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