FANCM Limits Meiotic Crossovers
2012
Crismani, Wayne | Girard, Chloé | Froger, Nicole | Pradillo, Mónica | Santos, Juan Luis | Chelysheva, Liudmila | Copenhaver, Gregory P. | Horlow, Christine | Mercier, Raphaël
No Crossing Over To ensure the correct division of chromosome during the reduction division of meiosis, homologous chromosomes undergo double-strand breaks that—through crossing over and recombination—link the homologs together (and importantly introduce diversity into the genomes of gametes). But only a minority of these crossovers results in recombination—most are directed into non-crossover pathways. Lorenz et al. (p. 1585), working in the yeast Schizosaccharomyces pombe , and Crismani et al. (p. 1588), working in the higher plant Arabidopsis thaliana , looked for the factors that limit crossovers and promote non-crossover pathways. The homolog of the human Fanconi anemia complementation group M (FANCM) helicase protein was found to be a major meiotic anti-recombinase, which could drive meiotic recombination intermediates into the non-crossover pathway.
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