Interaction of Histone H1 with cis-Platinum Modified DNA
2014
Paneva, Elena G. | Spassovska, Nadejda C. | Grancharov, Konstantin C. | Zlatanova, Jordanka S. | Yaneva, Julia N.
Cis-diamminedichloroplatinum(II) (cis-DDP) is known as an effective anticancer drug. Its therapeutic effect is supposed to be a consequence of the covalent binding to DNA. A number of cellular proteins were found to bind selectively to DNA modified by cis-DDP (but not by its isomer frans-DDP). Here we present our observations on interaction of the linker histone H1 with cis- and trans-DDP modified DNA fragments. The results afford new experimental information about the preferential binding of histone H1 to cis-DDP-distorted DNAs versus trans-DDP modified ones.
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