Robust Antibacterial Activity of Xanthan-Gum-Stabilized and Patterned CeO₂–ₓ–TiO₂ Antifog Films
2022
Guo, Fangwei | Pan, Fei | Zhang, Wenchen | Liu, Tian | Zuber, Flavia | Zhang, Xing | Yu, Yali | Zhang, Ruiji | Niederberger, Markus | Ren, Qun
Increased occurrence of antimicrobial resistance leads to a huge burden on patients, the healthcare system, and society worldwide. Developing antimicrobial materials through doping rare-earth elements is a new strategy to overcome this challenge. To this end, we design antibacterial films containing CeO₂–ₓ–TiO₂, xanthan gum, poly(acrylic acid), and hyaluronic acid. CeO₂–ₓ–TiO₂ inks are additionally integrated into a hexagonal grid for prominent transparency. Such design yields not only an antibacterial efficacy of ∼100% toward Staphylococcus aureus and Escherichia coli but also excellent antifog performance for 72 h in a 100% humidity atmosphere. Moreover, FluidFM is employed to understand the interaction in-depth between bacteria and materials. We further reveal that reactive oxygen species (ROS) are crucial for the bactericidal activity of E. coli through fluorescent spectroscopic analysis and SEM imaging. We meanwhile confirm that Ce³⁺ ions are involved in the stripping phosphate groups, damaging the cell membrane of S. aureus. Therefore, the hexagonal mesh and xanthan-gum cross-linking chains act as a reservoir for ROS and Ce³⁺ ions, realizing a long-lasting antibacterial function. We hence develop an antibacterial and antifog dual-functional material that has the potential for a broad application in display devices, medical devices, food packaging, and wearable electronics.
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