Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus
2001
Parshikov, I.A. | Freeman, J.P. | Lay, J.O. Jr | Moody, J.D. | Williams, A.J. | Beger, R.D. | Sutherland, J.B.
To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts were analyzed by liquid chromatography. The two metabolites (26% and 15% of the A280, respectively) were identified by mass and 1H nuclear magnetic resonance spectra as N-acetylsarafloxacin and desethylene-N-acetylsarafloxacin. The biological formation of desethylene-N-acetylsarafloxacin has not been previously observed.
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