An evolution revolution provides further revelation
2007
Lupski, James R.
The extent of copy-number variation (CNV) in the human genome has been appreciated only recently. Nevertheless, for almost four decades, gene duplication has been a prevailing hypothesis for evolutionary change. Recently, gene CNV spanning 60 million years of human and primate evolution has been determined1 enabling lineage-specific gene CNV to be identified. Primate lineage-specific gene CNV studies reveal that almost one third of all human genes exhibit a copy-number change in one or more primate species. Intriguingly, human lineage-specific gene amplification can be correlated to the emergence of human-specific traits such as cognition and endurance running. © 2007 Wiley Periodicals, Inc. BioEssays 29:1182-1184, 2007. © 2007 Wiley Periodicals, Inc.
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