127 : Role of TGF-beta signaling in circulating and tissue resident memory CD8⁺ T cells
2013
Ishigame, Harumichi | Sanjabi, Shomyseh | Flavell, R. A. (Richard A.)
Tissue resident memory (Trm) CD8⁺ T cells are a newly described memory T cell populations that are distinct from circulating memory T cells. The Trm CD8⁺ T cell responses are critical for protection against pathogens that invade the host via skin and mucosal tissues. Transforming growth factor-βeta (TGF-βeta) is thought to be important for controlling the numbers of KLRG⁺ effector T cells and promoting the residence of the Trm CD8⁺ T cells in several nonlymhpoid tissues including intestine. We will present data on how TGF-βeta signaling differentially regulates circulating and tissue resident memory CD8⁺ T cells after systemic infection with Listeria monocytogenes in mice.
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