A brief history behind the most used local anesthetics
2020
Bezerra, Marco M. | Leão, Raquel A.C. | Miranda, Leandro S.M. | de Souza, Rodrigo O.M.A.
The chemistry behind the discovery of local anesthetics is a beautiful way of understanding the development and improvement of medicinal/organic chemistry protocols towards the synthesis of biologically active molecules. Here in we present a brief history based on the chemistry development of the most used local anesthetics trying to draw a line between the first achievements obtained by the use of cocaine until the synthesis of the mepivacaine analogs nowadays.
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