Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones
2022
Frank, Aziza | Hamidi, Negar | Xue, Fengtian
We report a cesium bicarbonate-mediated alkylation of 2,4-dihydroxybenzyaldehyde and 2,4-dihydroxyacetophenone to generate 4-alkylated products in acetonitrile at 80 °C with excellent regioselectivity, up to 95% isolated yields, and broad substrate scope.
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Bibliographic information
Publisher
John Wiley & Sons, Ltd
Other Subjects
Scalable; Cesium bicarbonate; Acetonitrile; Alkylation; Regioselective; Alkylation; Regioselectivity
Language
English
Type
Journal Article; Text
2024-02-27
MODS
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