Chiral N,N′-dioxide/Sc(OTf)₃ complex-catalyzed asymmetric dearomatization of β-naphthols
2017
Ge, Shulin | Kang, Tengfei | Lin, Lili | Zhang, Xiying | Zhao, Peng | Liu, Xiaohua | Feng, Xiaoming
An efficient N,N′-dioxide–scandium(iii) complex catalytic system has been developed for the asymmetric dearomatization of β-naphthols through conjugate addition to alkynones. A variety of Z-predominated β-naphthalenone compounds were obtained in moderate to high yields with excellent enantioselectivities (up to 98% ee). Moreover, a possible transition state was proposed to explain the origin of the stereoselectivity.
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