Nucleolus: A Protein Quality Control Compartment
2019
Rekulapally, Pavani | Suresh, S.N.
Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat-shock protein (Hsp)70-dependent manner. This liquid–liquid phase separation (LLPS)-mediated nuclear quality control mechanism is perturbed during neurodegeneration.
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