Enhanced levels of multicatalytic proteinase mRNAs in Rous sarcoma virus transformed cells
1992
Balson, D.F. | Skilton, H.E. | Sweeney, S.T. | Thomson, S. | Rivett, A.J.
The multicatalytic proteinase (proteasome; MCP) is a high molecular mass proteinase which is found in all eukaryotic cells. Northern blot analysis of the levels of MCP mRNAs in a Rat-1 fibroblast cell line and in cells transformed with Rous sarcoma virus showed marked increases in the transformed cells. However, the results of immunoblot analysis with anti-MCP antibodies suggested that the MCP protein content of the two cell lines was similar.
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