Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen

Eisele, J.L.; Tello, D.; Osinaga, E.; Roseto, A.; Alzari, P.M.

Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen

1993

Eisele, J.L. | Tello, D. | Osinaga, E. | Roseto, A. | Alzari, P.M.

Isolectin B4 isolated from Vicia villosa seeds is specific for the Tn antigen, a carcinoma-associated molecular marker. Crystals of the isolectin grown in the presence of carbohydrate are tetragonal, space group P4(1) (or P4(3)), with a = 91.3 angstroms, c = 151.7 angstroms and one tetramer in the asymmetric unit. The crystals diffract X-rays to 2.8 angstroms resolution and are suitable for high-resolution structural analysis.

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AGROVOC Keywords

antigens chemistry crystallization crystallization humans lectins lectins methods vicia villosa

Bibliographic information

Published in

Journal of molecular biology

ISSN 0022-2836

Publisher

New York : Springer-Verlag

Other Subjects

X-ray diffraction; Molecular conformation; Carbohydrate; Tumor-associated; Macromolecular substances; Crystals; Isolectin b4; Isolation & purification; Crystal structure; X-ray diffraction; Acetylgalactosamine

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-27

Format: MODS

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Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen

1993

AGROVOC Keywords

Bibliographic information