Safety of a thickened extensive casein hydrolysate formula
2016
Vandenplas, Yvan | De Greef, Elisabeth | Xinias, I. | Vrani, O. | Mavroudi, A. | Hammoud, M. | Al Refai, F. | Khalife, M.C. | Sayad, A. | Noun, P. | Faraḥ, Adībah | Makhoul, G. | Orel, R. | Sokhn, M. | L'Homme, A. | Mohring, M.P. | Merhi, B Abou | Boulos, J. | El Masri, H. | Halut, C.
Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA.Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF.A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study.The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.
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