B-190 (Indralin) in Light of the History of the Formation of Ideas about the Mechanism of Action of Radioprotectors
2021
Vasin, M. V.
The history of the discovery of radioprotectors from the group of aminothiols and biogenic amines and of the formation of an idea about the mechanism of their action is presented. An analysis of the achievements of domestic scientists, radiation pharmacologists, and chemists is conducted. The role of the Institute of Aviation and Space Medicine, the Institute of Biophysics of the Ministry of Health, and Mendeleev Moscow Institute of Chemical Technology in the synthesis and development of an emergency radioprotector, B‑190 (indralin), is noted. The mechanism of pharmacological, radioprotective, and radiomitigative effect of indralin and its advantages over known radioprotectors are presented. The critical role of tissue hypoxia due to increased oxygen consumption against circulatory hypoxia under the action of α1-adrenomimetic radioprotector indralin in the implementation of its radioprotective properties in large animals (dogs and monkeys) is discussed. Radiomitigative effect of indralin occurs mainly through 5-H2 cherotonin receptors.
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