Lactic dehydrogenase virus (LDV) infection inhibits allergic eosinophil reaction in the airway
2002
Morimoto, M. | Ohji, T. | Iwata, H. | Hayashi, T.
The effects of interferon (IFN)-gamma induced by virus infection on eosinophil reaction in allergic airway inflammation are not yet clear. We investigated the effects of lactic dehydrogenase virus (LDV) infection, which increases IFN-gamma production with no viral infection or replication in respiratory epithelium, on allergic airway hypersensitivity. LDV infection suppressed antigen-induced eosinophil recruitment into the airway in sensitized mice. IL-5 gene expression in bronchoalveolar lavage (BAL) cells was significantly suppressed in LDV-infected mice compared with uninfected controls. The numbers of total T cells and CD4+ T cells were significantly reduced in LDV-infected mice compared with controls. The present results suggested that the increase in production of IFN-gamma by viral infection suppresses the eosinophil reaction, and this suppressive effect may be mediated by inhibition of the recruitment of CD4+ T cell and IL-5 production.
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