The association between three promoter polymorphisms of IL-1 and stroke: A meta-analysis
2015
Zou, Liwei | Zhao, Hong | Gong, Xijun | Jiang, Anhong | Guan, Song | Wang, Longsheng | Zheng, Suisheng
The association between Interleukin-1 (IL-1) gene polymorphism and stroke remains controversial. The present study was designed to clarify this relationship through a pooled analysis of the numerous epidemiological studies focusing on this association.Published data addressing the association between polymorphism of the IL-1 gene and stroke were selected from electronic databases. A total of 21 studies from 19 publications including 5280 stroke patients and 5699 controls were included in this meta-analysis which detect whether IL-1α-889C/T, IL-1β-511C/T and IL-1 RN polymorphism were associated with stroke susceptibility.The combined results of overall analysis revealed that there was a significant association between IL-1α-889C/T polymorphism and stroke (allele model: OR=1.39, 95% CI=1.14–1.68, P<0.001; recessive model: OR=1.56, 95% CI=1.27–1.90, P<0.001; dominant model: OR=1.45, 95% CI=1.13–1.87, P=0.004; additive model: OR=1.70, 95% CI=1.37–2.10, P<0.001). On a subgroup analysis by ethnicity of study population, significant association was found in Asians (allele model: OR=1.25 95% CI=1.12–1.39, P<0.001; recessive model: OR=1.36, 95% CI=1.09–1.69, P=0.007; dominant model: OR=1.29, 95% CI=1.12–1.48, P<0.001; additive model: OR=1.42, 95% CI=1.13–1.80, P=0.003). There are no associations of IL-1β-511C/T and IL-RN polymorphisms on stroke risk were identified.In conclusion, our results suggested that IL-1α-889C/T polymorphism is associated with stroke risk, especially in Asians. However, no associations of IL-1β-511C/T and IL-RN polymorphisms on stroke risk in overall analysis or subgroup analysis.
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