Dietary caffeine, glucose tolerance and insulin sensitivity in mice
1979
Araujo, P.E. | Mayer, J.
Mice fed high-fat, corn starch or sucrose diets containing 0.13 mg of caffeine per calorie of diet exhibited a more rapid return of blood glucose to resting levels during an oral glucose tolerance test, than did mice fed the same diets without added caffeine. This changed ability to respond to an oral glucose load represents a metabolic adaptation to chronic caffeine ingestion over the 4 week experimental period. The data demonstrated significant differences in relation to type of diet and insulin sensitivity with respect to caffeine adaptation and glucose uptake; caffeine increased fat tissue response to insulin except in sucrose-consuming mice. High caffeine levels may mimic the effect of a fast by increasing lipolysis, with sucrose feeding decreasing caffeine's effects. When mice were given caffeine chronically in their drinking water, a greater glycogen level in the diaphragm of caffeine-drinkers was observed, providing evidence that muscle adapts its ability to increase glycogen stores in the presence of caffeine. No differences in tissue cholesterol levels were seen between the 2 groups of mice.
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