Dual-mode biosensing platform for sensitive and portable detection of hydrogen sulfide based on cuprous oxide/gold/copper metal organic framework heterojunction
2023
Shang, Hongyuan | Ding, Meili | Zhang, Xiaofei | Zhang, Wen
Hydrogen sulfide (H₂S) can not only be regarded as a critical gas signal transduction substance, but also its excess levels can lead to a range of diseases. Currently, the accurate analysis combined with electrochemical (EC) or photothermal (PT) technology for H₂S in a complex biological system remains a significant challenge. Herein, an endogenous H₂S-triggered heterojunction cuprous oxide/gold/copper metal organic framework (Cu₂O/Au/HKUST-1) nanoprobe is designed for dual-mode EC- second near-infrared (NIR-II)/PT analysis in tumor cells with high sensitivity and simplicity. Dual-mode EC quantification - PT is achieved through “off–on” mode of EC and PT signals based on electronic transfer and biosynthesis via an in situ sulfuration reaction. Under the optimum conditions, the EC quantification mode for trace H₂S exhibits a wide linear range and an excellent limit of detection of 0.1 μM. More importantly, the dual-mode can display the selective detection of trace H₂S in living tumor cells because of the specific interaction between copper ion and H₂S. These results provide a new EC-PT promising biosensing platform for noninvasive intelligent detection of H₂S in living tumor cells.
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