Comparison between mandibular and femur derived bone marrow stromal cells: osteogenic and angiogenic potentials in vitro and bone repairing ability in vivo
2017
Zhou, Wenhui | Zhang, Jinkai | Lin, Kaili | Chen, Fengshan
As seed cells for bone tissue engineering, bone marrow stromal cells (BMSCs) have multiple differentiation potential. Prior studies have demonstrated that jaw bone has distinct osteogenic characteristics and different bone repairing capability from limb bone. In order to compare the promotion of bone regeneration as seed cells between maxillofacial derived BMSCs (M-BMSCs) and femur derived BMSCs (F-BMSCs) of SD rats, their proliferation and potential multipotent differentiation abilities, osteogenic differentiation and angiogenic factor secretion were investigated and compared. Moreover, the M-BMSCs and F-BMSCs were seeded on β-tricalcium phosphate bioceramic microspheres, and implanted into alveolar bone crest. The bone regeneration ability induced by the M-BMSCs and F-BMSCs was examined. The results showed that M-BMSCs had better osteogenic capability and angiogenic tendency than those of F-BMSCs both in vitro and in vivo. M-BMSCs might be the ideal stem seed cell sources for bone regeneration and bone tissue engineering applications.
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