Two new α-pinene derivatives from Angelica sinensis and their anticoagulative activities
2011
Yang, Nian-Yun | Zhou, Gui-Sheng | Tang, Yu-Ping | Yan, Hui | Guo, Sheng | Liu, Pei | Duan, Jin'ao | Song, Bing-Sheng | He, Zi-Qing
Two new α-pinene derivatives (1–2) were isolated from the aerial parts of Angelica sinensis. Their structures were determined by spectroscopic and chemical methods to be 6β,9-dihydroxy-(+)-α-pinene (1) and 9-hydroxy-(+)-α-pinene-6β-O-D-glucoside (2). In the anticoagulative assay, compounds 1 and 2 exhibited weak antithrombin activity and strong antiplatelet aggregation activity in vitro.
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