Denosumab-induced severe hypocalcemia in a patient with Paget's disease of bone and impaired renal function
2016
Kostine, Marie | Mehsen-Cetre, Nadia | Bannwarth, Bernard
Paget's disease of bone is characterised by focal areas of increased bone turnover affecting one or several bones throughout the skeleton. Where indicated, pharmacological management is primarily based on the use of anti-resorptive drugs. In this respect, bisphosphonates are the drugs of choice. However, they are contraindicated in patients with advanced renal dysfunction. Here, we report the efficacy and safety of one denosumab injection (60mg) in a patient with Paget's disease of bone and impaired renal function, who benefited from this treatment but developed a severe hypocalcemia.
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